# Proprietary Technologies

The range of technologies we have accumulated over a history spanning

more than nine decades has proven to be a powerful asset.

This section showcases some of Yamamoto Chemicals' proprietary technologies.

## Specialized reactions and precision technologies

### Specialized reactions

- Electrophilic substitution reaction
- Halogenation, nitration, sulfonation, Friedel-Crafts, formylation

- Nucleophilic substitution reaction
- Alkoxylation, amination, thioaklylation

- Condensation reaction
- Esterification, amidation, imidation, etherification, heterocyclization

- Addition reaction
- Diels‐Alder reaction

- Reduction reaction
- Hydrogenation reaction, sodium hydrosulfide reduction reaction

- C-C binding reaction
- Ullmann reaction- Suzuki coupling- Sonogashira reaction

- C-N binding reaction
- Diazonium coupling reaction- N-allylation

### Purification technologies

#### Sublimation refining

#### Freeze drying

## Proprietary compounds

- Phthalocyanine compounds
- Naphthalocyanine compounds
- Tetraazaporphyrin compounds
- Anthraquinone compounds
- Azo compounds (typical structures)

- Cyanine compounds
- Fluoran compounds
- Quinophthalone compounds

## Proprietary reactions and technologies

### Reactions using sulfuric acid

Dehydration-condensation reaction | Triphenylmethane derivative |
---|---|

Anthraquinone derivative | |

Triphenylmethane derivative |

### Reactions using aluminum chloride

Acylation reaction | Benzoyl derivative |
---|---|

Benzoyl ketone derivative |

### Reactions using acetic anhydride

Acetylation reaction | N-, C-acetyl derivative |
---|---|

Dehydration-condensation reaction | Phthalide derivative |

### Reactions using dialkyl sulfite

Alkylation reaction | N-Methyl derivative |
---|---|

N-Ethyl derivative |

### Reactions using alkyl halide

N-Alkylation reaction | N-Alkyl derivative |
---|---|

N-Dialkyl derivative | |

O-Alkylation reaction | Alkoxy derivative |

Esterification reaction | Ester derivative |

### Reactions using aryl halide

N-Aryl reaction | N-Aryl derivative |
---|---|

N-Diaryl derivative | |

N-Triaryl derivative | |

O-Aryl reaction | Phenoxy derivative |

### Reactions using sodium nitrite

Diazotization reaction | Azo dye |
---|---|

Tetrazotization reaction | Azo dye |

### Reactions using chlorosulfuric acid

Chlorosulfonation reaction | Sulfonyl derivative |
---|---|

Sulfonic acid derivative |

### Carbon-carbon cross coupling reaction

Bisaryl derivative |

### Heterocyclic forming reaction

Indole derivative |

Isoindole derivative |

Pyrrole derivative |

Barbituric acid derivative |

Phenothiazine derivative |

### Vilsmeier reaction

Formylation reaction |

Cyanation reaction |

### Halogenation reaction

Bromination reaction |

Chlorination reaction |

### Other

Phthalocyanine derivative |

Naphthalocyanine derivative |

Tetraazaporphyrin derivative |

Cyanine derivative |

Azo metal complex |

## Contact Us

For consultations or queries regarding

Yamamoto Chemicals and its products,

feel free to contact us via telephone

or the email inquiry form.

### Telephone queries: [Tokyo Office]

+81-3-6402-2191Weekdays 9:00 a.m. to 5:00 p.m.,

closed Saturdays, Sundays and public holidays